Unit V AAssessment#3 Oxidative Stress Essay Example | Topics and Well Written Essays - 250 words

Unit V AAssessment#3 Oxidative Stress - Essay Example In order to eavaluate thr ability of particulate air pollution to promote oxidative stress, six adult pathogen free Sprague-Dawley rats were obtained from Taconic Farms in New York,USA, and fed with conventional laboratory diet and water ad libium.Three of the rats were exposed to filtered air (control group) and the other three were exposed to concentrated ambient particles (CAPs). Throughout the study, all rats were awake and unrestricted. At 1, 3 and 5 hours, two rats: 1 from filtered air and 1 from CAPs , were removed and analysed. The rats that were exposed to CAPs aerosols for 5 hours showed significant oxidative stress. The rats showed significant increase in lung and heart water content (about 5% , p According to Gurgueira, et al., (2002 p.260), the generation of ROS can induce cellular oxidative stress and biological effects,including DNA damage.In most aerobic cells, electron –transport chains are located in mitochondria and the endoplasmic reticulum . The electron –transport chains are the major source of ROS produced in vivo (Gurjar, et al., 2010: p.190). Gurgueira, S. A., Lawrence, J., Coull, B., Murthy, K. G. G., & Gonzà ¡lez-Flecha, B. ( 2002). Rapid increases in the steady-state concentration of reactive oxygen species in the lungs and heart after particulate air pollution inhalation. Environmental Health Perspectives, 110(8),